Drug details:
Classification: Polypeptides; Organic Polymers; Organic compounds;

Curated SMILES: CC(C)[C@H](NC(=O)[C@H](C)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)B1O[C@H]2[C@H]3C[C@@H](C[C@@]2(C)O1)C3(C)C

Evidence for compound's anti-virulence activity:

Mycobacterium
Related VF: ESX-1 (ESAT-6 secretion system-1)
Target: MycP1
Drug effect: Inhibits the MycP1 protease that is essential for ESX-1 function.
Max phase: Preclinical (in vitro)
Publication:
Frasinyuk MS, et al., 2014. Pentapeptide boronic acid inhibitors of Mycobacterium tuberculosis MycP1 protease. Bioorg Med Chem Lett 24(15):3546-8.