Drug details:
Molecular formula: C₂₃H₁₉N₃O₇

Standard name: 2-[[2-(furan-2-carbonylamino)-3-(3-nitrophenyl)prop-2-enoyl]amino]-3-phenylpropanoic acid

Curated SMILES: O=C(N/C(=C\C1=CC=CC([N+](=O)[O-])=C1)C(=O)NC(CC1=CC=CC=C1)C(=O)O)C1=CC=CO1

Evidence for compound's anti-virulence activity:

Mycobacterium
Related VFcategory: Exoenzyme
Target: Zmp1
Drug effect: Inhibits the Mycobacterium tuberculosis extracellular zinc metalloprotease 1 (Zmp1) that is essential for phagosome maturation and bacterial intracellular survival.
Max phase: Preclinical (in vitro)
Publication:
Mori M, et al., 2014. Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor. Bioorg Med Chem Lett 24(11):2508-11.