Drug details:
Molecular formula: C₁₆H₁₅ClN₄O₄S

Standard name: 2-[7-[(4-chlorophenyl)methyl]-1,3-dimethyl-2,6-dioxopurin-8-yl]sulfanylacetic acid

Synonym:

{[7-(4-chlorobenzyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]sulfanyl}acetic acid

Curated SMILES: CN1C2=C(C(=O)N(C1=O)C)N(C(=N2)SCC(=O)O)CC3=CC=C(C=C3)Cl

Evidence for compound's anti-virulence activity:

Mycobacterium
Related VFcategory: Exoenzyme
Target: Zmp1
Drug effect: Inhibits the Mycobacterium tuberculosis extracellular zinc metalloprotease 1 (Zmp1) that is essential for phagosome maturation and bacterial intracellular survival.
Max phase: Preclinical (in vitro)
Publication:
Mori M, et al., 2014. Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor. Bioorg Med Chem Lett 24(11):2508-11.