Drug details:
Molecular formula: C₂₀H₁₅NO₅S₂

Standard name: 4-[(Z)-[3-[(1R)-1-carboxy-2-phenylethyl]-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]benzoic acid

Synonym:

4-[(Z)-[3-[(1R)-1-benzyl-2-hydroxy-2-oxo-ethyl]-4-oxo-2-thioxo-thiazolidin-5-ylidene]methyl]benzoic acid

Curated SMILES: C1=CC=C(C=C1)C[C@H](C(=O)O)N2C(=O)/C(=C/C3=CC=C(C=C3)C(=O)O)/SC2=S

Evidence for compound's anti-virulence activity:

Mycobacterium
Related VFcategory: Exoenzyme
Target: Zmp1
Drug effect: Inhibits the Mycobacterium tuberculosis extracellular zinc metalloprotease 1 (Zmp1) that is essential for phagosome maturation and bacterial intracellular survival.
Max phase: Preclinical (in vitro)
Publication:
Mori M, et al., 2014. Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor. Bioorg Med Chem Lett 24(11):2508-11.