Drug details:
Molecular formula: C₁₇H₁₇N₃O₃S

Standard name: 2-(6-ethyl-4-oxothieno[2,3-d]pyrimidin-3-yl)-N-(2-methoxyphenyl)acetamide

Curated SMILES: CCC1=CC2=C(N=CN(CC(=O)NC3=CC=CC=C3OC)C2=O)S1

Evidence for compound's anti-virulence activity:

Mycobacterium
Related VFcategory: Immune modulation
Target: CdnP
Drug effect: Inhibits bacterial phosphodiesterase (PDE) CdnP activity that responsible for cleaving bacterial c-di-AMP as well as host-derived cGAMP to blunt the host's response to infection.
Max phase: Preclinical (in vitro)
Publication:
Karanja CW, et al., 2021. Identification of a Mycobacterium tuberculosis Cyclic Dinucleotide Phosphodiesterase Inhibitor. ACS Infect Dis 7(2):309-317.