Drug details:
Molecular formula: C₁₄H₉ClN₂O₃S₂

Standard name: 1-(5-chlorothiophen-2-yl)-2-[[5-(4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone

Curated SMILES: C1=CC(=CC=C1C2=NN=C(O2)SCC(=O)C3=CC=C(S3)Cl)O

Evidence for compound's anti-virulence activity:

Mycobacterium
Related VF: ESX-1 (ESAT-6 secretion system-1)
Target: EthR
Drug effect: Activating ethionamide by binding to EthR and inhibiting ESX1-mediated secretion of virulence factors.
Max phase: Preclinical (in vitro)
Publication:
Gries R, et al., 2024. Discovery of dual-active ethionamide boosters inhibiting the Mycobacterium tuberculosis ESX-1 secretion system. Cell Chem Biol 31(4):699-711.e6.