Drug details:
Molecular formula: C₁₈H₂₃N₃O₂S

Standard name: 1-(azepan-1-yl)-3-[[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]propan-1-one

Synonym:

1-(azepan-1-yl)-3-{[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}propan-1-one

Curated SMILES: CC1=CC(=CC=C1)C2=NN=C(O2)SCCC(=O)N3CCCCCC3

Evidence for compound's anti-virulence activity:

Mycobacterium
Related VF: ESX-1 (ESAT-6 secretion system-1)
Target: Not determined
Drug effect: Inhibits ESX1-mediated secretion of virulence factors EsxA and EsxB.
Max phase: Preclinical (in vitro)
Publication:
Gries R, et al., 2024. Discovery of dual-active ethionamide boosters inhibiting the Mycobacterium tuberculosis ESX-1 secretion system. Cell Chem Biol 31(4):699-711.e6.