Drug details:
Molecular formula: C₂₉H₂₅N₅O₆

Standard name: 6-hydroxy-3-[1-[2-(4-morpholin-4-ylanilino)-2-oxoethyl]triazol-4-yl]-2-phenyl-1-benzofuran-5-carboxylic acid

Synonyms:

6-hydroxy-3-[1-[2-(4-morpholinoanilino)-2-oxo-ethyl]triazol-4-yl]-2-phenyl-benzofuran-5-carboxylic acid 6-hydroxy-3-(1-(2-((4-morpholinophenyl)amino)-2-oxoethyl)-1H-1,2,3-triazol-4-yl)-2-phenylbenzofuran-5-carboxylic acid 6-hydroxy-3-[1-[2-(4-morpholin-4-ylanilino)-2-oxoethyl]triazol-4-yl]-2-phenyl-1-benzofuran-5-carboxylic acid (3R,4aR,6S,8S)-10-(3,4-Dihydroxybenzoyl)-2,2,7,7-tetramethyl-3,6,8-tris(3-methylbut-2-en-1-yl)-3,4,5,6,7,8-hexahydro-2H,9H-4a,8-methanocycloocta[b]pyran-9,11-dione 6-hydroxy-3-(1-(2-(4-morpholinophenylamino)-2-oxoethyl)-1H-1,2,3-triazol-4-yl)-2-phenylbenzofuran-5-carboxylic acid 6-Hydroxy-3-[1-[2-[[4-(4-morpholinyl)phenyl]amino]-2-oxoethyl]-1H-1,2,3-triazol-4-yl]-2-phenyl-5-benzofurancarboxylic acid

Curated SMILES: C1COCCN1C2=CC=C(C=C2)NC(=O)CN3C=C(N=N3)C4=C(OC5=CC(=C(C=C54)C(=O)O)O)C6=CC=CC=C6

Evidence for compound's anti-virulence activity:

Mycobacterium
Related VFcategory: Exoenzyme
Target: PtpB
Drug effect: Inhibits protein tyrosine phosphatase B (PtpB) to interfere with signal transduction pathways in macrophages.
Max phase: Preclinical (in vitro)
Publication:
Zhou B, et al., 2010. Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents. Proc Natl Acad Sci U S A 107(10):4573-8.