Drug details:
Molecular formula: C₁₄H₁₂N₂O

Standard name: (2Z)-2-[1-[5-(1H-pyrrol-2-yl)furan-2-yl]ethylidene]pyrrole

Synonyms:

1H-Pyrrole, 2-[5-[(1Z)-1-(2H-pyrrol-2-ylidene)ethyl]-2-furanyl]- 2-(5-{1-[(2Z)-2H-pyrrol-2-ylidene]ethyl}furan-2-yl)-1H-pyrrole hydrochloride, 5

Curated SMILES: C/C(=C/1\C=CC=N1)/C2=CC=C(O2)C3=CC=CN3

Evidence for compound's anti-virulence activity:

Mycobacterium
Related VFcategory: Exoenzyme
Target: PtpA
Drug effect: Inhibits protein tyrosine phosphatase PtpA to disrupt phagosome acidification and maturation.
Max phase: Preclinical (in vitro)
Publication:
Manger M, et al., 2005. Discovery of Mycobacterium tuberculosis protein tyrosine phosphatase A (MptpA) inhibitors based on natural products and a fragment-based approach. Chembiochem 6(10):1749-53.