Drug details:
Molecular formula: C₃₁H₂₉N₃O₅

Standard name: 3-[[(2S)-2-(3-benzoyl-1-cyanoindolizin-5-yl)oxy-4-methylpentanoyl]amino]-3-phenylpropanoic acid

Curated SMILES: CC(C)C[C@@H](C(=O)NC(CC(=O)O)C1=CC=CC=C1)OC2=CC=CC3=C(C=C(N32)C(=O)C4=CC=CC=C4)C#N

Evidence for compound's anti-virulence activity:

Mycobacterium
Related VFcategory: Exoenzyme
Target: PtpB
Drug effect: Inhibits protein tyrosine phosphatase B (PtpB) to interfere with signal transduction pathways in macrophages.
Max phase: Preclinical (in vitro)
Publication:
Weide T, et al., 2006. 3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors. Bioorg Med Chem Lett 16(1):59-63.