Drug details:
Molecular formula: C₂₃H₁₄ClF₂N₃O₆S

Standard name: 1'-[(4-chlorophenyl)methyl]-3-(3,4-difluorophenyl)-5'-nitro-1,1-dioxospiro[1,3-thiazolidine-2,3'-indole]-2',4-dione

Synonyms:

1-(4-Chlorobenzyl)-3'-(3,4-difluorophenyl)-5-nitro-4'H-spiro[indole-3,2'-[1,3]thiazolidine]-2,4'(1H)-dione 1',1'-dioxide 1-(4-Chlorobenzyl)-5-nitro-3'-(3,4-difluorophenyl)-2,4'-dioxospiro[indoline-3,2'-thiazolidine]1',1'-dioxide

Curated SMILES: O=C1CS(=O)(=O)C2(C(=O)N(CC3=CC=C(Cl)C=C3)C3=CC=C([N+](=O)[O-])C=C32)N1C1=CC(F)=C(F)C=C1

Evidence for compound's anti-virulence activity:

Mycobacterium
Related VFcategory: Exoenzyme
Target: PtpB
Drug effect: Inhibits protein tyrosine phosphatase B (PtpB) to interfere with signal transduction pathways in macrophages.
Max phase: Preclinical (in vitro)
Publication:
Vintonyak VV, et al., 2010. Identification of thiazolidinones spiro-fused to indolin-2-ones as potent and selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase B. Angew Chem Int Ed Engl 49(34):5902-5.