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1'-[(3-chlorophenyl)methyl]-3-(3,4-difluorophenyl)-5'-nitro-1,1-dioxo-spiro[1,3-thiazolidine-2,3'-indoline]-2',4-dione

Drug details:
Molecular formula: C23H14ClF2N3O6S

Classification: Amino acids, peptides, and analogues; Carboxylic acids and derivatives; Organic acids and derivatives; Organic compounds;
Synonym:  1-(3-Chlorobenzyl)-3'-(3,4-difluorophenyl)-5-nitro-4'H-spiro[indole-3,2'-[1,3]thiazolidine]-2,4'(1H)-dione 1',1'-dioxide

Chemical structure:
Depiction based on curated SMILES N + N O _ O F F N S O O O O Cl

Evidence for compound's anti-virulence activity:

Mycobacterium
Related VFcategory: Exoenzyme
Target: PtpB
Drug effect: Inhibits protein tyrosine phosphatase B (PtpB) to interfere with signal transduction pathways in macrophages.
Max phase: Preclinical (in vitro)
Publication:
Vintonyak VV, et al., 2010. Identification of thiazolidinones spiro-fused to indolin-2-ones as potent and selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase B. Angew Chem Int Ed Engl 49(34):5902-5.








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