Drug details:
Molecular formula: C₂₄H₁₄F₂N₄O₆S

Standard name: 4-[[3-(3,4-difluorophenyl)-5'-nitro-1,1,2',4-tetraoxospiro[1,3-thiazolidine-2,3'-indole]-1'-yl]methyl]benzonitrile

Synonym:

4-{[3'-(3,4-Difluorophenyl)-5-nitro-1',1'-dioxido-2,4'-dioxospiro[indole-3,2'-[1,3]thiazolidin]-1(2H)-yl]methyl}benzonitrile

Curated SMILES: N#CC1=CC=C(CN2C(=O)C3(C4=CC([N+](=O)[O-])=CC=C42)N(C2=CC(F)=C(F)C=C2)C(=O)CS3(=O)=O)C=C1

Evidence for compound's anti-virulence activity:

Mycobacterium
Related VFcategory: Exoenzyme
Target: PtpB
Drug effect: Inhibits protein tyrosine phosphatase B (PtpB) to interfere with signal transduction pathways in macrophages.
Max phase: Preclinical (in vitro)
Publication:
Vintonyak VV, et al., 2010. Identification of thiazolidinones spiro-fused to indolin-2-ones as potent and selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase B. Angew Chem Int Ed Engl 49(34):5902-5.