Drug details:
Molecular formula: C₂₅H₁₆BrF₂N₃O₈S

Standard name: 2-[1'-[(4-bromophenyl)methyl]-3-(3,4-difluorophenyl)-5'-nitro-1,1,2',4-tetraoxospiro[1,3-thiazolidine-2,3'-indole]-5-yl]acetic acid

Curated SMILES: O=C(O)CC1C(=O)N(C2=CC(F)=C(F)C=C2)C2(C(=O)N(CC3=CC=C(Br)C=C3)C3=CC=C([N+](=O)[O-])C=C32)S1(=O)=O

Evidence for compound's anti-virulence activity:

Mycobacterium
Related VFcategory: Exoenzyme
Target: PtpB
Drug effect: Inhibits protein tyrosine phosphatase B (PtpB) to interfere with signal transduction pathways in macrophages.
Max phase: Preclinical (in vitro)
Publication:
Vintonyak VV, et al., 2010. Identification of thiazolidinones spiro-fused to indolin-2-ones as potent and selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase B. Angew Chem Int Ed Engl 49(34):5902-5.