Drug details:
Molecular formula: C₂₁H₂₂N₂O₂S

Standard name: N-(2-methylcyclohexyl)-6-oxo-5H-benzo[b][1,4]benzothiazepine-3-carboxamide

Curated SMILES: CC1CCCCC1NC(=O)C2=CC3=C(C=C2)SC4=CC=CC=C4C(=O)N3

Evidence for compound's anti-virulence activity:

Staphylococcus
Related VF: α-hemolysin
Target: SaeS
Drug effect: Inhibits the kinase activity of SaeS to repress exotoxin production.
Max phase: Preclinical (in vivo)
Publication:
Arya R, et al., 2023. Identification of an antivirulence agent targeting the master regulator of virulence genes in Staphylococcus aureus. Front Cell Infect Microbiol 13:1268044.