Drug details:
Classification: Pyrrolidones; Pyrrolidines; Organoheterocyclic compounds; Organic compounds;

Curated SMILES: C1C=CC(CN2C(=O)C([Se]C3C=CC=CC=3)=C([Se]C3C=CC=CC=3)C2=O)=CC=1

Evidence for compound's anti-virulence activity:

Staphylococcus
Related VFcategory: Biofilm
Target: Not determined
Drug effect: Inhibits biofilm formation in a sarX-dependent manner.
Max phase: Preclinical (in vivo)
Publication:
Xiao Y, et al., 2024. Novel small-molecule compound YH7 inhibits the biofilm formation of Staphylococcus aureus in a sarX-dependent manner. mSphere 9(1):e0056423.