Drug details:
Molecular formula: C₁₉H₁₅NO₄S₂

Standard name: 2-[(5Z)-4-oxo-5-[(4-phenylmethoxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid

Synonyms:

(Z)-2-(5-(4-(benzyloxy)benzylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid 3-Thiazolidineacetic acid, 4-oxo-5-[[4-(phenylmethoxy)phenyl]methylene]-2-thioxo-, (5Z)- 2-[(5Z)-4-oxo-5-[(4-phenylmethoxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid 2-(5-(4-(Benzyloxy)benzylidene)-4-oxo-2-thioxothiazolidin-3-yl)aceticacid (5Z)-4-Oxo-5-[[4-(phenylmethoxy)phenyl]methylene]-2-thioxo-3-thiazolidineacetic acid {5-[1-(4-Benzyloxy-phenyl)-meth-(Z)-ylidene]-4-oxo-2-thioxo-thiazolidin-3-yl}-acetic acid 2-[(5Z)-5-[(4-benzyloxyphenyl)methylene]-4-oxo-2-thioxo-thiazolidin-3-yl]acetic acid

Curated SMILES: C1=CC=C(C=C1)COC2=CC=C(C=C2)/C=C\3/C(=O)N(C(=S)S3)CC(=O)O

Evidence for compound's anti-virulence activity:

Staphylococcus
Related VF: α-hemolysin
Target: ClpP
Drug effect: A noncompetitive inhibitor of ClpP and represses expression of virulence factors including α-toxin and protein A in a ClpP-dependent manner.
Max phase: Preclinical (in vivo)
Publication:
Gao P, et al., 2018. Suppression of Staphylococcus aureus virulence by a small-molecule compound. Proc Natl Acad Sci U S A 115(31):8003-8008.