Drug details:
Molecular formula: C₁₂H₁₂N₂OS₂

Standard name: 4-ethylsulfanyl-2-phenyl-5-sulfanylpyridazin-3-one

Synonyms:

4-(ethylthio)-5-mercapto-2-phenyl-3(2H)-pyridazinone 4-(ethylsulfanyl)-2-phenyl-5-sulfanylpyridazin-3(2h)-one

Curated SMILES: CCSC1=C(C=NN(C1=O)C2=CC=CC=C2)S

Evidence for compound's anti-virulence activity:

Staphylococcus
Related VFcategory: Others
Target: SrtA
Drug effect: Blocks sortase-catalyzed cleavage and transpeptidation reactions with LPXTG substrate peptides and inhibited the incorporation of surface proteins into the staphylococcal envelope.
Max phase: Preclinical (in vitro)
Publication:
Suree N, et al., 2009. Discovery and structure-activity relationship analysis of Staphylococcus aureus sortase A inhibitors. Bioorg Med Chem 17(20):7174-85.