Drug details:
Molecular formula: C₁₈H₂₀N₂O₃S

Standard name: (E)-N-[3-(hydroxymethyl)-4-morpholin-4-ylphenyl]-3-thiophen-2-ylprop-2-enamide

Curated SMILES: C1COCCN1C2=C(C=C(C=C2)NC(=O)/C=C/C3=CC=CS3)CO

Evidence for compound's anti-virulence activity:

Staphylococcus
Related VFcategory: Others
Target: SrtA
Drug effect: Blocks sortase-catalyzed cleavage and transpeptidation reactions with LPXTG substrate peptides and inhibited the incorporation of surface proteins into the staphylococcal envelope.
Max phase: Preclinical (in vitro)
Publication:
Chenna BC, et al., 2010. Synthesis and structure activity relationship studies of novel Staphylococcus aureus Sortase A inhibitors. Eur J Med Chem 45(9):3752-61.