VFDB - anti-virulence compound 4-(2-amino-1H-imidazol-4-yl)-N-dodecyl-butyramide hydrochloride

Acinetobacter

Aeromonas

Anaplasma

Bacillus

Bartonella

Bordetella

Brucella

Burkholderia

Campylobacter

Chlamydia

Clostridium

Corynebacterium

Coxiella

Enterococcus

Escherichia

Francisella

Haemophilus

Helicobacter

Klebsiella

Legionella

Listeria

Mycobacterium

Mycoplasma

Neisseria

Pseudomonas

Rickettsia

Salmonella

Shigella

Staphylococcus

Streptococcus

Vibrio

Yersinia

4-(2-amino-1H-imidazol-4-yl)-N-dodecyl-butyramide hydrochloride

Drug details:
Molecular formula: C₁₉H₃₇ClN₄O

Standard name: 4-(2-amino-1H-imidazol-5-yl)-N-dodecylbutanamide;hydrochloride

Classification: Fatty amides; Fatty Acyls; Lipids and lipid-like molecules; Organic compounds;

Curated SMILES: CCCCCCCCCCCCNC(=O)CCCC1=CN=C(N1)N.Cl

Chemical structure:

Evidence for compound's anti-virulence activity:

Staphylococcus
Related VFcategory: Regulation
Target: VicR
Drug effect: Inhibits biofilm formation via binding to VicR, a key response regulator.
Max phase: Preclinical (in vivo)
Publication:
Liu C, et al., 2023. Small Molecule Attenuates Bacterial Virulence by Targeting Conserved Response Regulator. mBio 14(3):e0013723.


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