Drug details:
Molecular formula: C₂₁H₂₀O₁₀

Standard name: 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one

Synonyms:

Saponaretin Homovitexin 6-Glucosylapigenin Apigenin-6-C-glucoside 6-C-Glucosylapigenin Isoavroside Avroside Apigenin 6-C-glucoside beta-D-isovitexin ......

Curated SMILES: C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C=C(C(=C3O)[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O)O

Evidence for compound's anti-virulence activity:

Staphylococcus
Related VFcategory: Others; Adherence
Target: SrtA
Drug effect: Inhibits SrtA activity and reduces ability to adhere and invade host cells.
Max phase: Preclinical (in vivo)
Publication:
Tian L, et al., 2022. Isovitexin Protects Mice from Methicillin-Resistant Staphylococcus aureus-Induced Pneumonia by Targeting Sortase A. J Microbiol Biotechnol 32(10):1284-1291.