Drug details:
Molecular formula: C₁₆H₁₂O₅

Standard name: 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one

Synonyms:

Oroxylin 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one 5,7-dihydroxy-6-methoxyflavone 5,7-dihydroxy-6-methoxy-2-phenyl-4H-1-benzopyran-4-one 6-Methoxybaicalein 4H-1-Benzopyran-4-one, 5,7-dihydroxy-6-methoxy-2-phenyl- 5,7-dihydroxy-6-methoxy-2-phenyl-4H-chromen-4-one baicalein 6-methyl ether Baicalein 6-methyl ether ......

Curated SMILES: COC1=C(C2=C(C=C1O)OC(=CC2=O)C3=CC=CC=C3)O

Evidence for compound's anti-virulence activity:

Staphylococcus
Related VFcategory: Others
Target: SrtA
Drug effect: Inhibits SrtA activity and SrtA-related virulence phenotypes including adhesion and invasion to the host, biofilm formation.
Max phase: Preclinical (in vitro)
Publication:
Jiang X, et al., 2023. Oroxylin a glucuronide as a novel class of reversible inhibitors of Sortase a, combats MRSA-induced infections. J Appl Microbiol 134(5):lxad089.