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Compound category: Naphthalenes
(total 4 related compounds in database)
 
Compound name 2D structure Target pathogen(s) Related VF/VFcategory Max phase Reference(s)
N-(furan-2-ylmethylcarbamoyl)-2-(4-oxobenzo[g]quinazolin-3-yl)acetamide Depiction based on curated SMILES O N H O HN O O N N Shigella TTSS (Type III secretion system) Preclinical (in vivo) Case HB, et al. 2020. Biochemistry
[2-[[(1R,2R)-2-methylcyclohexyl]carbamoylamino]-2-oxoethyl] 4-oxo-3-phenylphthalazine-1-carboxylate Depiction based on curated SMILES N N O O N H H H H 3 C O N H O O Shigella TTSS (Type III secretion system) Preclinical (in vivo) Case HB, et al. 2020. Biochemistry
2-phenyl-2,3-dihydrophthalazine-1,4-dione Depiction based on curated SMILES O O N HN Shigella VirF Preclinical (in vitro) Hurt JK, et al. 2010. J Biomol Screen
4-chloro-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide Depiction based on curated SMILES Cl O OH N N H Chlamydia
Salmonella
Shigella		 TTSS (Type III secretion system)
TTSS (SPI-1 encode); TTSS (SPI-2 encode)
TTSS (Type III secretion system)		 Preclinical (in vitro)
Preclinical (in vitro)
Preclinical (in vitro)		 Muschiol S, et al. 2006. Proc Natl Acad Sci U S A
Negrea A, et al. 2007. Antimicrob Agents Chemother
Veenendaal AK, et al. 2009. J Bacteriol
   
   
   
   
   
   
   
   
   
   
   
   
   


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