Drug details:
Molecular formula: C₇H₈N₂O₃

Standard name: N-(2,5-dihydroxyphenyl)-N-methylnitrous amide

Synonyms:

1,4-Benzenediol, 2-(methylnitrosoamino)- N-(2,5-dihydroxyphenyl)-N-methylnitrous amide 2-(Methylnitrosoamino)-1,4-benzenediol 2-[(hydroxyamino)-methylamino]cyclohexa-2,5-diene-1,4-dione 2-(N-methyl-N-nitroso)hydroquinone 1,4-Dihydroxy-N-methyl-N-nitrosoaniline 1,4-Benzenediol,2-(methylnitrosoamino)- 2-[methyl(nitroso)amino]benzene-1,4-diol 2-(2-Hydroxy-1-methylhydrazinyl)cyclohexa-2,5-diene-1,4-dione

Curated SMILES: CN(C1=C(C=CC(=C1)O)O)N=O

Evidence for compound's anti-virulence activity:

Salmonella
Related VF: PmrAB; SsrAB
Target: Not determined
Drug effect: Perturbs regulatory signaling by interacting with SsrB and PmrA.
Max phase: Preclinical (in vivo)
Publication:
Tsai CN, et al., 2020. Targeting Two-Component Systems Uncovers a Small-Molecule Inhibitor of Salmonella Virulence. Cell Chem Biol 27(7):793-805.e7.