Drug details:
Molecular formula: C₂₄H₁₇ClN₄O₂S

Standard name: N-[2-[4-(benzimidazol-1-yl)anilino]-2-oxoethyl]-3-chloro-1-benzothiophene-2-carboxamide

Curated SMILES: O=C(CNC(=O)C1=C(Cl)C2=CC=CC=C2S1)NC1=CC=C(N2C=NC3=CC=CC=C32)C=C1

Evidence for compound's anti-virulence activity:

Salmonella
Related VF: TTSS (SPI-1 encode)
Target: Not determined
Drug effect: Prohibits the expression of the main SPI-1 transcription regulator InvF.
Max phase: Preclinical (in vitro)
Publication:
Boonyom R, et al., 2022. A small molecule, C(24)H(17)ClN(4)O(2)S, inhibits the function of the type III secretion system in Salmonella Typhimurium. J Genet Eng Biotechnol 20(1):54.

Yersinia
Related VF: TTSS (Type III secretion system)
Target: YscN
Drug effect: Blocks translocation of Yop effectors.
Max phase: Preclinical (in vivo)
Publication:
Swietnicki W, et al., 2011. Identification of small-molecule inhibitors of Yersinia pestis Type III secretion system YscN ATPase. PLoS One 6(5):e19716.