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Compound category: Phenylbenzimidazoles
(total 8 related compounds in database)
 
Compound name 2D structure Target pathogen(s) Related VF/VFcategory Max phase Reference(s)
N-[4-(1-hydroxy-6-nitrobenzimidazol-2-yl)phenyl]-4-(1,3-oxazol-5-yl)benzamide Depiction based on curated SMILES HO N N + N O _ O N H O O N Yersinia TTSS (Type III secretion system) Preclinical (in vivo) Garrity-Ryan LK, et al. 2010. Infect Immun
(E)-3-(4-Acetyl-phenyl)-N-[4-(1-hydroxy-6-nitro-1H-benzoimidazol-2-yl)-phenyl]-acrylamide Depiction based on curated SMILES N + N O _ O N HO H 3 C N H O O Pseudomonas TTSS (Type III secretion system) Preclinical (in vitro) Marsden AE, et al. 2016. Antimicrob Agents Chemother
(E)-3-(4-acetylphenyl)-N-(4-(6-cyano-1-hydroxy-1H-benzo[d]imidazol-2-yl)phenyl)acrylamide Depiction based on curated SMILES HO N N N H 3 C N H O O Pseudomonas TTSS (Type III secretion system) Preclinical (in vitro) Marsden AE, et al. 2016. Antimicrob Agents Chemother
(E)-3-(4-fluorophenyl)-N-[4-(1-hydroxy-6-nitrobenzimidazol-2-yl)phenyl]prop-2-enamide Depiction based on curated SMILES HO N _ O O + N N O N H F Pseudomonas
Yersinia
Yersinia		 TTSS (Type III secretion system)
TTSS (Type III secretion system)
TTSS (Type III secretion system)		 Preclinical (in vitro)
Preclinical (in vitro)
Preclinical (in vivo)		 Marsden AE, et al. 2016. Antimicrob Agents Chemother
Kim OK, et al. 2009. J Med Chem
Garrity-Ryan LK, et al. 2010. Infect Immun
4-fluoro-N-[4-(1-hydroxy-6-nitrobenzimidazol-2-yl)phenyl]benzamide Depiction based on curated SMILES O F OH N _ O O + N N N H Pseudomonas TTSS (Type III secretion system) Preclinical (in vitro) Marsden AE, et al. 2016. Antimicrob Agents Chemother
N-[2-[4-(benzimidazol-1-yl)anilino]-2-oxoethyl]-3-chloro-1-benzothiophene-2-carboxamide Depiction based on curated SMILES N H N N O S Cl O N H Salmonella
Yersinia		 TTSS (SPI-1 encode)
TTSS (Type III secretion system)		 Preclinical (in vitro)
Preclinical (in vivo)		 Boonyom R, et al. 2022. J Genet Eng Biotechnol
Swietnicki W, et al. 2011. PLoS One
(E)-3-(4-fluorophenyl)-N-[4-(1-hydroxy-5-methyl-6-nitrobenzimidazol-2-yl)phenyl]prop-2-enamide Depiction based on curated SMILES O N H 3 C + N _ O N OH H F O N Yersinia TTSS (Type III secretion system) Preclinical (in vitro) Kim OK, et al. 2009. J Med Chem
(E)-N-[4-(1-hydroxy-6-nitrobenzimidazol-2-yl)phenyl]-3-(4-methoxyphenyl)prop-2-enamide Depiction based on curated SMILES _ O O + N OH N N CH 3 N H O O Yersinia TTSS (Type III secretion system) Preclinical (in vitro) Kim OK, et al. 2009. J Med Chem
   
   
   
   
   


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