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3,5-dichloro-N-[2-(2-chlorophenyl)-5-hydroxy-4-oxo-4H-chromen-8-yl]-2-hydroxybenzenesulfonamide

Drug details:
Molecular formula: C21H12Cl3NO6S

Classification: Flavones; Flavonoids; Phenylpropanoids and polyketides; Organic compounds;
Chemical structure:
Depiction based on curated SMILES O HO OH Cl Cl O O S N H O Cl

Evidence for compound's anti-virulence activity:

Salmonella
Related VF: TTSS (SPI-2 encode)
Target: SseK1/SseK2
Drug effect: Inhibits SseK1/SseK2 Arg glycosyltransferase activity.
Max phase: Preclinical (in vitro)
Publication:
El Qaidi S, et al., 2018. High-Throughput Screening for Bacterial Glycosyltransferase Inhibitors. Front Cell Infect Microbiol 8:435.








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