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Pirlindole mesylate

Drug details:
Molecular formula: C16H22N2O3S

Classification: Carbazoles; Indoles and derivatives; Organoheterocyclic compounds; Organic compounds;
Synonyms:  8-methyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole methanesulfonate
2,3,3a,4,5,6-Hexahydro-8-methyl-1H-pyrazino[3,2,1-j,k]carbazolemesylate
methanesulfonic acid
12-methyl-1,4-diazatetracyclo[7.6.1.05,16.010,15]hexadeca-9(16),10(15),11,13-tetraene
8-Methyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino-[3,2,1-jk]carbazole methanesulfonate
Pirlindole (mesylate)
1H-Pyrazino[3,2,1-jk]carbazole,2,3,3a,4,5,6-hexahydro-8-methyl-
2,3,3a,4,5,6-Hexahydro-8-methyl-1H-pyrazino[3,2,1-j,k]carbazole mesylate
8-methyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazolemethanesulfonate

Chemical structure:
Depiction based on curated SMILES HO O O S CH 3 CH 3 HN N

Evidence for compound's anti-virulence activity:

Salmonella
Related VFcategory: Invasion
Target: Not determined
Drug effect: Inhibits bacterial invasion and intracellular replication.
Max phase: Preclinical (in vitro)
Publication:
Ridge Y, et al., 2018. High-throughput screening of a collection of known pharmacologically active small compounds for inhibitors of Salmonella invasion and intracellular replication. J Appl Microbiol 125(3):724-730.








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