Drug details:
Molecular formula: C₈H₇NO

Standard name: 1H-indol-5-ol

Synonyms:

1H-Indol-5-ol 5-Hydroxy-1H-indole Hydroxy-5 indole 5-hydroxy-indole Hydroxy-5 indole [French] EINECS 217-782-6 Hydroxy-5 indole [French] 5-hydroxylindole 5-hydroxy-indol ......

Curated SMILES: OC1=CC=C2NC=CC2=C1

Evidence for compound's anti-virulence activity:

Salmonella
Related VF: TTSS (SPI-1 encode)
Target: SipB/SspB; SipD
Drug effect: Interacts with the Salmonella translocon protein SipB and the tip protein SipD to inhibit T3SS secretion.
Max phase: Preclinical (in vitro)
Publication:
McShan AC, et al., 2016. Characterization of the Binding of Hydroxyindole, Indoleacetic acid, and Morpholinoaniline to the Salmonella Type III Secretion System Proteins SipD and SipB. ChemMedChem 11(9):963-71.

Shigella
Related VF: TTSS (Type III secretion system)
Target: IpaD
Drug effect: Inhibits transcriptional activator.
Max phase: Preclinical (in vitro)
Publication:
Dey S, et al., 2017. Characterization of Small-Molecule Scaffolds That Bind to the Shigella Type III Secretion System Protein IpaD. ChemMedChem 12(18):1534-1541.