Drug details:
Molecular formula: C₂₀H₂₇FN₂S

Standard name: 1-[1-[2-(2-fluorophenyl)ethyl]piperidin-4-yl]-N-methyl-N-(thiophen-3-ylmethyl)methanamine

Curated SMILES: CN(CC1CCN(CC1)CCC2=CC=CC=C2F)CC3=CSC=C3

Evidence for compound's anti-virulence activity:

Salmonella
Related VFcategory: Biofilm
Target: Not determined
Drug effect: Inhibits biofilm formation and disrupts preformed biofilms.
Max phase: Preclinical (in vivo)
Publication:
Woolard KJ, et al., 2022. Development of small molecules that work cooperatively with ciprofloxacin to clear salmonella biofilms in a chronic gallbladder carriage model. Eur J Med Chem 232:114203.