Drug details:
Molecular formula: C₁₇H₁₉F₃N₂O₅

Standard name: [3-cyclopropyl-5-hydroxy-5-(trifluoromethyl)-4H-pyrazol-1-yl]-(3,4,5-trimethoxyphenyl)methanone

Synonym:

[3-cyclopropyl-5-hydroxy-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl](3,4,5-trimethoxyphenyl)methanone

Curated SMILES: COC1=CC(=CC(=C1OC)OC)C(=O)N2C(CC(=N2)C3CC3)(C(F)(F)F)O

Evidence for compound's anti-virulence activity:

Acinetobacter
Related VFcategory: Biofilm
Target: DGC
Drug effect: Inhibits of diguanylate cyclase (DGC) enzymes that synthesize c-di-GMP that is essential for biofilm formation.
Max phase: Preclinical (in vitro)
Publication:
Sambanthamoorthy K, et al., 2015. Modulating Acinetobacter baumannii biofilm development with molecules containing 3,4,5-trimethoxy-N,N',N'-trimethylbenzohydrazide moiety. Bioorg Med Chem Lett 25(10):2238-42.