Drug details:
Molecular formula: C₂₁H₂₀O₆

Standard name: (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione

Synonyms:

Diferuloylmethane Natural yellow 3 Indian saffron Kacha haldi Curcuma Gelbwurz Haldar Curcumin I Souchet ......

Curated SMILES: COC1=CC(/C=C/C(=O)CC(=O)/C=C/C2=CC(OC)=C(O)C=C2)=CC=C1O

Evidence for compound's anti-virulence activity:

Acinetobacter
Related VF: BfmRS
Target: BfmR
Drug effect: Binds to BfmR, a response regulator that is the master controller of biofilm formation.
Max phase: Preclinical (in vitro)
Publication:
Raorane CJ, et al., 2019. Antibiofilm and Antivirulence Efficacies of Flavonoids and Curcumin Against Acinetobacter baumannii. Front Microbiol 10:990.

Bacillus
Related VFcategory: Biofilm
Target: LuxS/AI-2
Drug effect: Inhibits LuxS/AI-2 QS system to counteract bacterial pathogenicity and virulence.
Max phase: Preclinical (in vitro)
Publication:
Fernandes S, et al., 2023. Curcumin and 10-undecenoic acid as natural quorum sensing inhibitors of LuxS/AI-2 of Bacillus subtilis and LasI/LasR of Pseudomonas aeruginosa. Food Res Int 165:112519.

Clostridium
Related VF: Collagenase
Target: ColA
Drug effect: Inhibits collagenase activity to block the colonization and infiltration of the host by the bacteria.
Max phase: Preclinical (in vitro)
Publication:
Nitulescu G, et al., 2022. Discovery of New Microbial Collagenase Inhibitors. Life (Basel) 12(12):2114.

Enterococcus
Related VFcategory: Biofilm
Target: Not determined
Drug effect: Reducts biofilm formation.
Max phase: Preclinical (in vitro)
Publication:
Oda DF, et al., 2019. Antimicrobial action of photodynamic therapy in root canals using LED curing light, curcumin and carbopol gel. Int Endod J 52(7):1010-1019.

Pseudomonas
Related VF: Quorum sensing
Target: LasI
Drug effect: Inhibits QS system to counteract bacterial pathogenicity and virulence.
Max phase: Preclinical (in vitro)
Publication:
Fernandes S, et al., 2023. Curcumin and 10-undecenoic acid as natural quorum sensing inhibitors of LuxS/AI-2 of Bacillus subtilis and LasI/LasR of Pseudomonas aeruginosa. Food Res Int 165:112519.