Drug details:
Molecular formula: C₂₂H₁₉N₃O

Standard name: 1-[(3,5-dimethyl-1-phenylpyrazol-4-yl)iminomethyl]naphthalen-2-ol

Curated SMILES: CC1=NN(C2=CC=CC=C2)C(C)=C1/N=C/C1=C(O)C=CC2=CC=CC=C21

Evidence for compound's anti-virulence activity:

Pseudomonas
Related VF: TTSS (Type III secretion system)
Target: Not determined
Drug effect: Blocks translocation of effectors into host cells.
Max phase: Preclinical (in vitro)
Publication:
Harmon DE, et al., 2010. Identification and characterization of small-molecule inhibitors of Yop translocation in Yersinia pseudotuberculosis. Antimicrob Agents Chemother 54(8):3241-54.

Yersinia
Related VF: TTSS (Type III secretion system)
Target: Yops
Drug effect: Interferes with bacterial adherence.
Max phase: Preclinical (in vitro)
Publication:
Harmon DE, et al., 2010. Identification and characterization of small-molecule inhibitors of Yop translocation in Yersinia pseudotuberculosis. Antimicrob Agents Chemother 54(8):3241-54.