Drug details:
Molecular formula: C₁₆H₁₁N₃S

Standard name: 4-(1H-indol-3-yl)-2-pyridin-4-yl-1,3-thiazole

Synonym:

3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1H-indole

Curated SMILES: C1=CC=C2C(=C1)NC=C2C1=CSC(C2=CC=NC=C2)=N1

Evidence for compound's anti-virulence activity:

Pseudomonas
Related VF: TTSS (Type III secretion system)
Target: Not determined
Drug effect: Blocks translocation of effectors into host cells.
Max phase: Preclinical (in vitro)
Publication:
Harmon DE, et al., 2010. Identification and characterization of small-molecule inhibitors of Yop translocation in Yersinia pseudotuberculosis. Antimicrob Agents Chemother 54(8):3241-54.

Yersinia
Related VF: TTSS (Type III secretion system)
Target: Yops
Drug effect: Inhibits translocation of Yop effectors.
Max phase: Preclinical (in vitro)
Publication:
Harmon DE, et al., 2010. Identification and characterization of small-molecule inhibitors of Yop translocation in Yersinia pseudotuberculosis. Antimicrob Agents Chemother 54(8):3241-54.