VFDB - anti-virulence compound N-(4-cyanophenyl)-2-fluoro-N'-(4-phenoxyphenyl)propanediamide

Acinetobacter

Aeromonas

Anaplasma

Bacillus

Bartonella

Bordetella

Brucella

Burkholderia

Campylobacter

Chlamydia

Clostridium

Corynebacterium

Coxiella

Enterococcus

Escherichia

Francisella

Haemophilus

Helicobacter

Klebsiella

Legionella

Listeria

Mycobacterium

Mycoplasma

Neisseria

Pseudomonas

Rickettsia

Salmonella

Shigella

Staphylococcus

Streptococcus

Vibrio

Yersinia

N-(4-cyanophenyl)-2-fluoro-N'-(4-phenoxyphenyl)propanediamide

Drug details:
Molecular formula: C₂₂H₁₆FN₃O₃

Standard name: N-(4-cyanophenyl)-2-fluoro-N'-(4-phenoxyphenyl)propanediamide

Classification: Diphenylethers; Benzene and substituted derivatives; Benzenoids; Organic compounds;

Curated SMILES: N#CC1=CC=C(NC(=O)C(F)C(=O)NC2=CC=C(OC3=CC=CC=C3)C=C2)C=C1

Chemical structure:

Evidence for compound's anti-virulence activity:

Pseudomonas
Related VFcategory: Biofilm
Target: MvfR
Drug effect: Inhibits MvfR-regulated virulence functions.
Max phase: Preclinical (in vivo)
Publication:
Singh VK, et al., 2022. Tackling recalcitrant Pseudomonas aeruginosa infections in critical illness via anti-virulence monotherapy. Nat Commun 13(1):5103.


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