Drug details:
Molecular formula: C₂₂H₁₆F₄N₂O₃

Standard name: 2-fluoro-N-(4-phenoxyphenyl)-N'-[4-(trifluoromethyl)phenyl]propanediamide

Curated SMILES: C1=CC=C(C=C1)OC2=CC=C(C=C2)NC(=O)C(C(=O)NC3=CC=C(C=C3)C(F)(F)F)F

Evidence for compound's anti-virulence activity:

Pseudomonas
Related VFcategory: Biofilm
Target: MvfR
Drug effect: Inhibits MvfR-regulated virulence functions.
Max phase: Preclinical (in vitro)
Publication:
Singh VK, et al., 2022. Tackling recalcitrant Pseudomonas aeruginosa infections in critical illness via anti-virulence monotherapy. Nat Commun 13(1):5103.