Drug details:
Molecular formula: C₃₀H₂₈O₈

Standard name: (E)-1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethylchromen-8-yl]-3-phenylprop-2-en-1-one

Synonyms:

Mallotoxin Kamalin EINECS 201-395-4 (E)-1-(6-((3-Acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl)-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl)-3-phenyl-2-propen-1-one (E)-1-(6-(3-acetyl-2,4,6-trihydroxy-5-methylbenzyl)-5,7-dihydroxy-2,2-dimethyl-2H-chromen-8-yl)-3-phenylprop-2-en-1-one (E)-1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethylchromen-8-yl]-3-phenylprop-2-en-1-one 1-[6-(3-Acetyl-2,4,6-trihydroxy-5-methyl-benzyl)-5,7-dihydroxy-2,2-dimethyl-2H-chromen-8-yl]-3-phenyl-propenone 1-[6-[(3-Acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethylchromen-8-yl]-3-phenylprop-2-en-1-one 5-18-05-00695 (Beilstein Handbook Reference) ......

Curated SMILES: CC(=O)C1=C(O)C(CC2=C(O)C(C(=O)/C=C/C3=CC=CC=C3)=C3OC(C)(C)C=CC3=C2O)=C(O)C(C)=C1O

Evidence for compound's anti-virulence activity:

Pseudomonas
Related VFcategory: Biofilm
Target: DGC
Drug effect: Inhibits of diguanylate cyclase (DGC) enzymes that synthesize c-di-GMP that is essential for biofilm formation.
Max phase: Preclinical (in vitro)
Publication:
Sambanthamoorthy K, et al., 2014. Identification of small molecules inhibiting diguanylate cyclases to control bacterial biofilm development. Biofouling 30(1):17-28.