Drug details:
Molecular formula: C₁₀H₆O₃

Standard name: 5-hydroxynaphthalene-1,4-dione

Synonyms:

5-Hydroxy-1,4-naphthoquinone 5-Hydroxy-1,4-naphthalenedione 5-Hydroxynaphthalene-1,4-dione Regianin Nucin Juglon 5-Hydroxynaphthoquinone Akhnot Yuglon ......

Curated SMILES: C1=CC(=O)C2=C(C1=O)C(O)=CC=C2

Evidence for compound's anti-virulence activity:

Clostridium
Related VF: Collagenase
Target: ColA
Drug effect: Inhibits collagenase activity to block the colonization and infiltration of the host by the bacteria.
Max phase: Preclinical (in vitro)
Publication:
Nitulescu G, et al., 2022. Discovery of New Microbial Collagenase Inhibitors. Life (Basel) 12(12):2114.

Staphylococcus
Related VFcategory: Others; Biofilm
Target: SrtA
Drug effect: Inhibits biofilm formation.
Max phase: Preclinical (in vitro)
Publication:
Nitulescu G, et al., 2019. Discovery of natural naphthoquinones as sortase A inhibitors and potential anti-infective solutions against Staphylococcus aureus. Drug Dev Res 80(8):1136-1145.