Drug details:
Molecular formula: C₂₀H₂₅ClN₂O₅

Standard name: 3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Synonyms:

(R)-Amlodipine-d4 (RS)-3-ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate (RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate 2-(2-aminoethoxy)methyl-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine 2-[(2-Aminoethoxy)-methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5- pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzene sulfonate 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl) 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methylester 2-[2-Aminoethoxymethyl]-3-ethoxycarbonyl-4-(2-chlorophenyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine ......

Curated SMILES: C(OC(=O)C1=C(COCCN)N(C(=C(C(=O)OC)C1C2=CC=CC=C2Cl)C))C

Evidence for compound's anti-virulence activity:

Clostridium
Related VF: TcdB (Toxin B)
Target: Calcium channels on the plasma membrane
Drug effect: Disrupts of TcdB-induced calcium signaling thus to ablate ROS production and prevent subsequent necrosis.
Max phase: Preclinical (in vitro)
Publication:
Farrow MA, et al., 2020. Small Molecule Inhibitor Screen Reveals Calcium Channel Signaling as a Mechanistic Mediator of Clostridium difficile TcdB-Induced Necrosis. ACS Chem Biol 15(5):1212-1221.