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Compound category: Pyridines and derivatives
(total 13 related compounds in database, current show from 1 to 10)
 
Compound name 2D structure Target pathogen(s) Related VF/VFcategory Max phase Reference(s)
(3R)-5-Oxo-6-(dimethylaminomethyl)-7-(1-naphthylmethyl)-8-phenyl-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3beta-carboxylic acid lithium salt Depiction based on curated SMILES _ O N H 3 C N CH 3 + Li O H S O Escherichia Type 1 fimbriae; P fimbriae Preclinical (in vivo) Pinkner JS, et al. 2006. Proc Natl Acad Sci U S A
6-(2-chlorophenyl)-3-(4-pyridinyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole Depiction based on curated SMILES N Cl N S N N N Staphylococcus Others Preclinical (in vivo) Zhang J, et al. 2014. Proc Natl Acad Sci U S A
Sodium 3-(3-(pyridin-4-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl)benzenesulfonate Depiction based on curated SMILES N S N N N O N + Na _ O O S Staphylococcus Others Preclinical (in vivo) Zhang J, et al. 2014. Proc Natl Acad Sci U S A
Amlodipine Depiction based on curated SMILES CH 3 H 3 C Cl CH 3 O O HN H 2 N O O O Clostridium TcdB (Toxin B) Preclinical (in vitro) Farrow MA, et al. 2020. ACS Chem Biol
Nifedipine Depiction based on curated SMILES O _ O O + N H 3 C O CH 3 CH 3 NH CH 3 O O Clostridium TcdB (Toxin B) Preclinical (in vitro) Farrow MA, et al. 2020. ACS Chem Biol
Cetylpyridinium chloride Depiction based on curated SMILES _ Cl + N CH 3 Helicobacter BabA (Blood group antigen binding adhesin); Flagella; Urease Preclinical (in vitro) Xun M, et al. 2024. PLoS One
1-[2-[(4-fluorophenyl)methylamino]-2-oxo-ethyl]-N-[1-(4-methyl-5-vinyl-1H-imidazol-2-yl)ethyl]-6-oxo-pyridine-3-carboxamide Depiction based on curated SMILES H 2 C F NH O CH 3 O N O NH H 3 C N H N Mycobacterium Exoenzyme Preclinical (in vitro) Mori M, et al. 2014. Bioorg Med Chem Lett
Fusaric acid Depiction based on curated SMILES H 3 C N O HO Salmonella TTSS (SPI-1 encode) Preclinical (in vitro) Li J, et al. 2014. Biochem Biophys Res Commun
(E)-N'-(3,5-Dibromo-2-hydroxybenzylidene)nicotinohydrazide Depiction based on curated SMILES N OH Br O Br N N H Chlamydia
Escherichia
Salmonella		 TTSS (Type III secretion system)
TTSS (Type III secretion system)
TTSS (SPI-1 encode); TTSS (SPI-2 encode)		 Preclinical (in vitro)
Preclinical (in vitro)
Preclinical (in vitro)		 Bailey L, et al. 2007. FEBS Lett
Tree JJ, et al. 2009. Infect Immun; Wang D, et al. 2011. J Biol Chem
Negrea A, et al. 2007. Antimicrob Agents Chemother
Nicotinic acid (5-bromo-2-hydroxy-benzylidene)-hydrazide Depiction based on curated SMILES N OH O Br N N H Salmonella
Shigella		 TTSS (SPI-1 encode); TTSS (SPI-2 encode)
TTSS (Type III secretion system)		 Preclinical (in vitro)
Preclinical (in vitro)		 Negrea A, et al. 2007. Antimicrob Agents Chemother
Veenendaal AK, et al. 2009. J Bacteriol
   


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