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(3R)-5-Oxo-6-(dimethylaminomethyl)-7-(1-naphthylmethyl)-8-phenyl-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3beta-carboxylic acid lithium salt

Drug details:
Molecular formula: C28H25LiN2O3S

Classification: Phenylpyridines; Pyridines and derivatives; Organoheterocyclic compounds; Organic compounds;
Chemical structure:
Depiction based on curated SMILES _ O N H 3 C N CH 3 + Li O H S O

Evidence for compound's anti-virulence activity:

Escherichia
Related VF: Type 1 fimbriae; P fimbriae
Target: PapD
Drug effect: Blocking chaperone and usher functions.
Max phase: Preclinical (in vivo)
Publication:
Pinkner JS, et al., 2006. Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria. Proc Natl Acad Sci U S A 103(47):17897-902.








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