Drug details:
C28H25LiN2O3S
Phenylpyridines; Pyridines and derivatives; Organoheterocyclic compounds; Organic compounds;
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Evidence for compound's anti-virulence activity:
Type 1 fimbriae; P fimbriae
PapD
Blocking chaperone and usher functions.
Preclinical (in vivo)
Pinkner JS, et al., 2006. Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria. Proc Natl Acad Sci U S A 103(47):17897-902.
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