Drug details:
Molecular formula: C₁₃H₉Br₂N₃O₂

Standard name: N-[(E)-(3,5-dibromo-2-hydroxyphenyl)methylideneamino]pyridine-3-carboxamide

Synonyms:

N-[(E)-(3,5-dibromo-2-hydroxyphenyl)methylideneamino]pyridine-3-carboxamide N'-(3,5-dibromo-2-hydroxybenzylidene)nicotinohydrazide N'-[(1E)-(3,5-dibromo-2-hydroxyphenyl)methylene]nicotinohydrazide N'-[(E)-(3,5-dibromo-2-hydroxyphenyl)methylidene]nicotinohydrazide N'-[(E)-(3,5-dibromo-2-hydroxyphenyl)methylidene]pyridine-3-carbohydrazide

Curated SMILES: O=C(N/N=C/C1=CC(Br)=CC(Br)=C1O)C1=CC=CN=C1

Evidence for compound's anti-virulence activity:

Chlamydia
Related VF: TTSS (Type III secretion system)
Target: Not determined
Drug effect: Inhibits T3SS activity.
Max phase: Preclinical (in vitro)
Publication:
Bailey L, et al., 2007. Small molecule inhibitors of type III secretion in Yersinia block the Chlamydia pneumoniae infection cycle. FEBS Lett 581(4):587-95.

Escherichia
Related VF: TTSS (Type III secretion system)
Target: WrbA;Tpx;FolX
Drug effect: Global effects on virulence gene regulation and effectively reduce formation of actin pedestals in vitro.
Max phase: Preclinical (in vitro)
Publications:
Tree JJ, et al., 2009. Characterization of the effects of salicylidene acylhydrazide compounds on type III secretion in Escherichia coli O157:H7. Infect Immun 77(10):4209-20.
Wang D, et al., 2011. Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence-blocking compounds. J Biol Chem 286(34):29922-31.

Salmonella
Related VF: TTSS (SPI-1 encode); TTSS (SPI-2 encode)
Target: Not determined
Drug effect: Efficiently affected SPI1 and SPI2 activity.
Max phase: Preclinical (in vitro)
Publication:
Negrea A, et al., 2007. Salicylidene acylhydrazides that affect type III protein secretion in Salmonella enterica serovar typhimurium. Antimicrob Agents Chemother 51(8):2867-76.