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Compound category: Pyridinecarboxylic acids and derivatives
(total 5 related compounds in database)
 
Compound name 2D structure Target pathogen(s) Related VF/VFcategory Max phase Reference(s)
1-[2-[(4-fluorophenyl)methylamino]-2-oxo-ethyl]-N-[1-(4-methyl-5-vinyl-1H-imidazol-2-yl)ethyl]-6-oxo-pyridine-3-carboxamide Depiction based on curated SMILES H 2 C F NH O CH 3 O N O NH H 3 C N H N Mycobacterium Exoenzyme Preclinical (in vitro) Mori M, et al. 2014. Bioorg Med Chem Lett
Fusaric acid Depiction based on curated SMILES H 3 C N O HO Salmonella TTSS (SPI-1 encode) Preclinical (in vitro) Li J, et al. 2014. Biochem Biophys Res Commun
(E)-N'-(3,5-Dibromo-2-hydroxybenzylidene)nicotinohydrazide Depiction based on curated SMILES N OH Br O Br N N H Chlamydia
Escherichia
Salmonella		 TTSS (Type III secretion system)
TTSS (Type III secretion system)
TTSS (SPI-1 encode); TTSS (SPI-2 encode)		 Preclinical (in vitro)
Preclinical (in vitro)
Preclinical (in vitro)		 Bailey L, et al. 2007. FEBS Lett
Tree JJ, et al. 2009. Infect Immun; Wang D, et al. 2011. J Biol Chem
Negrea A, et al. 2007. Antimicrob Agents Chemother
Nicotinic acid (5-bromo-2-hydroxy-benzylidene)-hydrazide Depiction based on curated SMILES N OH O Br N N H Salmonella
Shigella		 TTSS (SPI-1 encode); TTSS (SPI-2 encode)
TTSS (Type III secretion system)		 Preclinical (in vitro)
Preclinical (in vitro)		 Negrea A, et al. 2007. Antimicrob Agents Chemother
Veenendaal AK, et al. 2009. J Bacteriol
5-cyano-6-[(4-methylphenyl)methylsulfanyl]pyridine-2-carboxylic acid Depiction based on curated SMILES N N HO O CH 3 S Escherichia
Yersinia		 TTSS (Type III secretion system)
TTSS (Type III secretion system)		 Preclinical (in vitro)
Preclinical (in vitro)		 Pan NJ, et al. 2009. Antimicrob Agents Chemother
   
   
   
   
   
   
   
   
   
   
   


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