Drug details:
Molecular formula: C₂₃H₂₄FN₅O₃

Standard name: N-[1-(4-ethenyl-5-methyl-1H-imidazol-2-yl)ethyl]-1-[2-[(4-fluorophenyl)methylamino]-2-oxoethyl]-6-oxopyridine-3-carboxamide

Curated SMILES: CC1=C(N=C(N1)C(C)NC(=O)C2=CN(C(=O)C=C2)CC(=O)NCC3=CC=C(C=C3)F)C=C

Evidence for compound's anti-virulence activity:

Mycobacterium
Related VFcategory: Exoenzyme
Target: Zmp1
Drug effect: Inhibits the Mycobacterium tuberculosis extracellular zinc metalloprotease 1 (Zmp1) that is essential for phagosome maturation and bacterial intracellular survival.
Max phase: Preclinical (in vitro)
Publication:
Mori M, et al., 2014. Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor. Bioorg Med Chem Lett 24(11):2508-11.