Drug details:
Molecular formula: C₁₇H₁₈N₂O₆

Standard name: dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Synonyms:

Adalat Procardia Procardia XL Cordipin Corinfar Adalat CC Fenihidine Citilat Oxcord ......

Curated SMILES: COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=C([N+](=O)[O-])C=CC=C1

Evidence for compound's anti-virulence activity:

Clostridium
Related VF: TcdB (Toxin B)
Target: Calcium channels on the plasma membrane
Drug effect: Disrupts of TcdB-induced calcium signaling thus to ablate ROS production and prevent subsequent necrosis.
Max phase: Preclinical (in vitro)
Publication:
Farrow MA, et al., 2020. Small Molecule Inhibitor Screen Reveals Calcium Channel Signaling as a Mechanistic Mediator of Clostridium difficile TcdB-Induced Necrosis. ACS Chem Biol 15(5):1212-1221.