Drug details:
Molecular formula: C₁₄H₈ClN₅S

Standard name: 6-(2-chlorophenyl)-3-pyridin-4-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

Synonyms:

6-(2-chlorophenyl)-3-pyridin-4-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 6-(2-chlorophenyl)-3-(4-pyridyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 6-(2-chlorophenyl)-3-(pyridin-4-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

Curated SMILES: C1=CC=C(C(=C1)C2=NN3C(=NN=C3S2)C4=CC=NC=C4)Cl

Evidence for compound's anti-virulence activity:

Staphylococcus
Related VFcategory: Others
Target: SrtA
Drug effect: Blocks sortase-catalyzed cleavage and transpeptidation reactions with LPXTG substrate peptides and inhibited the incorporation of surface proteins into the staphylococcal envelope.
Max phase: Preclinical (in vivo)
Publication:
Zhang J, et al., 2014. Antiinfective therapy with a small molecule inhibitor of Staphylococcus aureus sortase. Proc Natl Acad Sci U S A 111(37):13517-22.