Drug details:
Molecular formula: C₁₄H₈N₅NaO₃S₂

Standard name: sodium;3-(3-pyridin-4-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl)benzenesulfonate

Curated SMILES: O=S(=O)([O-][Na+])C1=CC=CC(/C2=N/N3C(=NN=C3C3=CC=NC=C3)S2)=C1

Evidence for compound's anti-virulence activity:

Staphylococcus
Related VFcategory: Others
Target: SrtA
Drug effect: Blocks sortase-catalyzed cleavage and transpeptidation reactions with LPXTG substrate peptides and inhibited the incorporation of surface proteins into the staphylococcal envelope.
Max phase: Preclinical (in vivo)
Publication:
Zhang J, et al., 2014. Antiinfective therapy with a small molecule inhibitor of Staphylococcus aureus sortase. Proc Natl Acad Sci U S A 111(37):13517-22.