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N'-[(E)-(5-bromo-2-hydroxyphenyl)methylidene]-2-phenylacetohydrazide

Drug details:
Molecular formula: C15H13BrN2O2

Classification: Phenylacetamides; Benzene and substituted derivatives; Benzenoids; Organic compounds;
Synonyms:  N'-(5-bromo-2-hydroxybenzylidene)-2-phenylacetohydrazide
N'-[(1E)-(5-bromo-2-hydroxyphenyl)methylene]-2-phenylacetohydrazide

Chemical structure:
Depiction based on curated SMILES N OH Br O N H

Evidence for compound's anti-virulence activity:

Chlamydia
Related VF: TTSS (Type III secretion system)
Target: Not determined
Drug effect: Inhibits T3SS activity.
Max phase: Preclinical (in vitro)
Publication:
Dahlgren MK, et al., 2010. Statistical molecular design of a focused salicylidene acylhydrazide library and multivariate QSAR of inhibition of type III secretion in the Gram-negative bacterium Yersinia. Bioorg Med Chem 18(7):2686-703.








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