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N-[(E)-(5-tert-butyl-2-hydroxyphenyl)methylideneamino]-4-methylbenzamide

Drug details:
Molecular formula: C19H22N2O2

Classification: Benzoic acids and derivatives; Benzene and substituted derivatives; Benzenoids; Organic compounds;
Chemical structure:
Depiction based on curated SMILES OH CH 3 H 3 C H 3 C CH 3 N N H O

Evidence for compound's anti-virulence activity:

Chlamydia
Related VF: TTSS (Type III secretion system)
Target: Not determined
Drug effect: Inhibits T3SS activity.
Max phase: Preclinical (in vitro)
Publication:
Dahlgren MK, et al., 2010. Statistical molecular design of a focused salicylidene acylhydrazide library and multivariate QSAR of inhibition of type III secretion in the Gram-negative bacterium Yersinia. Bioorg Med Chem 18(7):2686-703.








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