Drug details:
Molecular formula: C₄H₃FN₂O₂

Standard name: 5-fluoro-1H-pyrimidine-2,4-dione

Synonyms:

fluorouracil Fluoroplex Efudex Adrucil Carac Fluracil 5-fluoropyrimidine-2,4(1H,3H)-dione Fluoroblastin Queroplex ......

Curated SMILES: C1=C(C(=O)NC(=O)N1)F

Evidence for compound's anti-virulence activity:

Staphylococcus
Related VFcategory: Biofilm
Target: Not determined
Drug effect: Inhibits biofilm formation by interfering with AI-2 production and release.
Max phase: Preclinical (in vivo)
Publication:
Sedlmayer F, et al., 2021. 5-Fluorouracil blocks quorum-sensing of biofilm-embedded methicillin-resistant Staphylococcus aureus in mice. Nucleic Acids Res 49(13):e73.

Vibrio
Related VFcategory: Biofilm
Target: MTAN/LuxS
Drug effect: Inhitors MTAN and/or LuxS, two enzymes involved in biosynthesis of quorum-sensor autoinducer-2 (AI-2) to prevent biofilm formation.
Max phase: Preclinical (in vivo)
Publication:
Sedlmayer F, et al., 2021. 5-Fluorouracil blocks quorum-sensing of biofilm-embedded methicillin-resistant Staphylococcus aureus in mice. Nucleic Acids Res 49(13):e73.